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Your Advanced YDNA Results
DYS452
There is a difference in reporting nomenclature for DYS452 between some companies. Our reporting nomenclature matches the standard nomenclature used by the NIST. DNA-Fingerprint also used this reporting nomenclature, as does the SMGF. Results from Relative Genetics and other resellers who outsource from Relative Genetics do not follow NIST’s standard, and 19 must be added to those results in order to compare against the standard nomenclature.
DYS 463
There is a difference in reporting nomenclature for DYS463 between some companies. Our reporting nomenclature matches the standard nomenclature used by the NIST. DNA-Fingerprint also used this reporting nomenclature, as does the SMGF. Results from Relative Genetics and other resellers who outsource from Relative Genetics do not follow NIST’s standard, and 2 must be added to those results in order to compare against the standard nomenclature.
DYF371
DYF371 is usually a four copy marker like DYS464. Its alleles are located on the palindromes P1 and P5 on the Y chromosome.
See the palindromic map
One of the copies on P5 can carry a mutation in the flanking region from C to T. This T-type allele was discovered as an independent marker and was called DYS425. Our lab has developed a test to detect the C- and T-type alleles for all DYF371 STR alleles simultaneously. This test is called DYF371X. We can see the T-type alleles and the C-type alleles in different fluorescent colors, so we can label each allele with c or t. A normal person without a NULL at DYS425 would look like 10c-12t-13c-14c for example. You will notice that in a DYS425 NULL result you don't have a T-type allele. This is because a C-type allele has overwritten the T-type allele during the RecLOH event. Other haplotypes may have two T-type alleles that may have occurred by the reverse copying process. Consequently these persons will have two DYS425 alleles.
Some persons who get a DYF371 result may notice that they have an odd number of alleles at this marker (3 or 5). This occasionally happens if a deletion or duplication occurs at the large P1 palindrome. Asymmetric markers that are located on different palindromes make such events visible while regular multi-copy markers (like DYS459, CDY, DYS464) are hard to figure out their molar equivalents of alleles in each genome. If you have a deletion or duplication on P1, don't panic! Today we know that many (almost all) persons with abnormal palindromic conformations at P1 or P2 are still perfectly fertile and can produce healthy children. Even whole haplogroups (like N) carry a deletion at P1/P2 as one of their characteristic markers on their Y chromosome. If you want to find out more about possible RecLOH events, insertions or deletions on your Y chromosome we suggest ordering the markers from the Palindromic Pack (Panel 5).
Links:
RecLOH at Wikipedia
Presentation on Palindromic Markers at FTDNA conference 2006 by Thomas Krahn
This presentation document can be opened with the free open source software from Open Office
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